Will Time Machine interfere with SuperDuper?
 

Is it a problem if Time Machine runs while SD! is backing up?

This is on my wife's Intel iMac, OS X 10.5.1 and SD! 2.5 (84). Time Machine backs up to one Firewire drive and SD! backs up to another.

Btw, how's Taiko?

Shouldn't be a problem (unless you're copying Time Machine itself, in which case you should turn it off while copying it).

Taiko's doing great, thanks: he's at my feet now, itching to go for another walk...