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I do this: I have TWO external backup drives (in addition to Time Machine and a network drive), and keep one of them in a bank safe deposit box and one at home. Then once every month I clone my hard drive using SD and then swap it with the one at the bank. If my backup drive at home gets stolen, then at worst I've lost only a month of data (as opposed to ALL of it). It's not automatic, but is not that cumbersome, either. Even if you are lazy and only do this twice a year, well you can potentially only lose half a year of data at worst. Didn't you say your business depends on this data?
Off-site backup is crucial - besides theft, there is also risk of fire, accidental damage, lightning, etc.
You might also want to check out something like Jungle Disk to back up to Amazon S3. The data is encrypted and is stored on Amazon's geographically dispersed servers.
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